SL 0101-1 Supplier | CAS 77307-50-7

Cat. No. 2250 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

说明： Selective ribosomal S6 kinase (RSK) inhibitor

化学名： 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

纯度： ≥95% (HPLC)

说明书

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SL 0101-1

SL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

技术数据 for SL 0101-1

分子量	516.46
公式	C₂₅H₂₄O₁₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	77307-50-7
PubChem ID	14825856
InChI Key	SXOZSDJHGMAEGZ-UHFFFAOYSA-N
Smiles	O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SL 0101-1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.16	10

制备储备液 for SL 0101-1

以下数据基于产品分子量 516.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	19.36 mL	96.81 mL	193.63 mL
0.5 mM	3.87 mL	19.36 mL	38.73 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

产品说明书 for SL 0101-1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SL 0101-1

参考文献是支持产品生物活性的出版物。

Smith et al (2005) Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 65 1027 PMID:15705904

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID:17850214

Godeny and Sayeski (2006) ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol. 291 1308

Saha et al (2012) RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem.J. 447 159 PMID:22827337

If you know of a relevant reference for SL 0101-1, please let us know.

按标靶查看相关产品

RSK
Kinases

按产品操作查看相关产品

查看全部 RSK Inhibitors

关键词: SL 0101-1, SL 0101-1 supplier, Selective, p90, ribosomal, S6, kinases, RSK, inhibitors, inhibits, SL0101-1, 2250, Tocris Bioscience

7 篇 SL 0101-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SL 0101-1 的部分引用包括：

Kroczynska et al (2011) Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling. J Biol Chem 286 1147 PMID:21075852

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID:21143600

Al-Ejeh et al (2014) Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. J Biol Chem 5 3145 PMID:24762669

Gawecka et al (2012) PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131 1556 PMID:22213050

Roselli et al (2009) Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS One 4 e6011 PMID:19547699

Gawecka et al (2012) RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem 287 43424 PMID:23118220

Li et al (2012) Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. PLoS One 287 15923 PMID:22427657

您是否知道使用了 Tocris SL 0101-1 的优秀论文？请告知我们.

SL 0101-1 的评论

目前没有该产品的评论。 Be the first to review SL 0101-1 and earn rewards!

Have you used SL 0101-1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的新产品

MSC 1186

Cat. No. 7927

Potent and selective SRPK family inhibitor

PZ 3022

Cat. No. 7876

PanK Activator

MTK 458

Cat. No. 7980

PINK1 activator

CS 640

Cat. No. 7982

Potent CaM kinase I inhibitor

MU 1742

Cat. No. 7979

Potent and selective CK1α, CK1δ and CK1ε inhibitor

注册获取新产品电子邮件提醒

You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!

Submit Review

SL 0101-1 Supplier | CAS 77307-50-7 | SL01011 (2024)